Stable isotope labeling of nucleic acids.

Accelerating innovation & business.

Three-dimensional representation of the electron shell of a ribonucleic acid in blue with an isotope labeled nucleobase in red.

Products & services

Stable isotope labeling
of nucleic acids

What a difference a neutron makes.

The ¹³C / ¹⁵N / ²H-stable isotope labeled RNA phosphoramidites and triphosphates provided by innotope can be utilized to produce tailor made RNA oligonucleotides with the optimized isotope labeling pattern for follow up applications.

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Phosphoramidite bottles used for shipping RNA and DNA amidites from Innotope. These bottles can be connected directly to ABI synthesizers.

Mass Spectrometry
Standards

Same, but different.

Innotope offers “heavy” nucleotides and nucleosides with naturally occurring modifications as mass spectrometry standards, focusing on heavy epigenetic modifiers.

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Example of the spectrum obtained from a mass spectrometric study of an m6A nucleoside using a standard from Innotope.

Custom Small
Molecule Synthesis

Our synthesis know-how in your hands.

Innotope has a profound organic synthesis knowledge to support you throughout custom small molecule synthesis projects.

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Schematic representation of possible modifications of nucleosides, triphosphates, and phosphoramidites directly on the ribose or on the nucleobase.

Custom
Oligonucleotides

Ready to go.

By capitalizing on our stable isotope labeled RNA phosphoramidites and triphosphates innotope offers an oligonucleotide synthesis service for our customers. Do not hesitate to contact us for customoligonucleotide synthesis projects. We provide tailor made RNA oligonucleotides with stable isotope labelling patterns as needed for your project such as: